Juan "Jon" Toledo

As an Assistant Professor of Neurology and the Scientific Director of the Nantz National Alzheimer Center, I have dedicated my career to the intersection of clinical practice, biomarker research, and neuropathology. My multidisciplinary background, which includes a PhD in Neuroscience, a fellowship in movement disorders, and a diploma in Health Science Statistics, uniquely positions me to investigate the complex co-pathologies that drive cognitive and movement disorders.

My research focuses on the utility of biofluid and imaging biomarkers in Alzheimer’s Disease and related dementias. Leveraging large-scale repositories such as ADNI, PPMI, and NACC, I have worked extensively to characterize how overlapping pathologies influence clinical progression. My experience is grounded in both the laboratory and the clinic; I have spent six years working in a brain bank and have served as site Principal Investigator for five clinical trials, ensuring a comprehensive understanding of the disease from molecular signature to patient bedside.

Beyond my clinical and data expertise, I am a bilingual practitioner with a deep commitment to community engagement. I have led extensive outreach efforts within the Houston area, collaborating with organizations such as the Alzheimer's Association, AARP, and the Mexican Consulate to increase awareness and participation in NIH-sponsored research among diverse populations.

I lead the Houston ADRC Clinical Core. In this capacity, I provide the clinical and administrative oversight necessary to integrate our core missions. I lead diagnostic consensus meetings, oversee participant visits, and ensure the high-quality collection of biofluids and imaging to support the Biomarker Core and NCRAD. Furthermore, I bridge the gap between our scientific objectives and our community by working closely with the ORE Core to ensure participant retention and with the REC Core to mentor the next generation of clinical trialists.