Joshua Shulman

Joshua Shulman

Biomarker Core

Baylor College of Medicine (BCM)

Personal Statement

Progress in translational research requires investigators who can effectively bridge the traditional silos between clinical care, human genomics, and experimental biology. As a board-certified neurologist sub-specializing in memory and movement disorders, I possess a deep clinical understanding of the manifestations of Alzheimer’s disease, Parkinson’s disease, and related tauopathies, including Progressive Supranuclear Palsy and Corticobasal Syndrome. My research program leverages this clinical insight to drive discovery through a sophisticated, cross-species approach that integrates human genomics with functional investigation in the Drosophila melanogaster model.

For over two decades, I have utilized Drosophila to dissect the mechanisms of neurodegeneration, successfully integrating genome-wide association studies and whole-exome sequencing with functional validation. These efforts have led to leadership roles within the AD Sequencing Project, where I co-chair the Functional Genomics Consortium, as well as the AMP-AD Target Discovery Consortium and the TREAT-AD centers. My laboratory’s current research focuses on two primary pillars: first, the functional dissection of brain gene and protein expression networks relevant to synaptic proteostasis; and second, the role of lysosomal pathways in modulating neurodegenerative disease risk and progression.

As Director of the Baylor Center for Alzheimer’s and Neurodegenerative Diseases, I lead initiatives to resolve the inherent heterogeneity of these disorders by integrating comprehensive deep-phenotyping with genetic and metabolomic profiles. This includes long-standing collaborations, such as my work with Dr. Joe Masdeu at Houston Methodist, providing genetic analysis for UDS-AT(N) characterized cohorts. As a Co‑Investigator in the HADRC Biomarker Core, I apply my expertise in functional genomics while fostering new and existing collaborations to advance biomarker discovery and therapeutic strategies for AD.

Biography

Dr. Joshua M. Shulman, MD, PhD, is a Professor of Neurology, Neuroscience, and Molecular & Human Genetics at Baylor College of Medicine and a leading figure in translational neurogenetics. He serves as the founding Director of the Baylor Center for Alzheimer’s and Neurodegenerative Diseases and the Co-Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital. A board-certified neurologist specializing in memory and movement disorders, Dr. Shulman remains clinically active at facilities such as Baylor St. Luke's Medical Center, where he cares for patients with Alzheimer’s, Parkinson’s, and related neurodegenerative conditions.

Dr. Shulman’s research mission is to bridge the gap between basic genetics and clinical neurology by integrating human genomic analysis with functional investigation in experimental models like Drosophila melanogaster. His laboratory's innovative "bench-to-bedside" approach has revealed key pathways in endolysosomal sorting, RNA metabolism, and synaptic proteostasis, earning him prestigious accolades such as the Burroughs Wellcome Fund Career Award and the American Neurological Association's Derek Denny-Brown Young Neurological Scholar Award. He currently holds the Huffington Foundation Endowed Chair for Parkinson’s Disease Research and the Effie Marie Cain Chair in Alzheimer’s Disease Research.

Dr. Shulman earned his medical degree summa cum laude from Harvard Medical School and a PhD in Genetics from the University of Cambridge. He completed his neurology residency and sub-specialty fellowship training through the Harvard/Partners Program at Brigham & Women’s Hospital and Massachusetts General Hospital before joining the BCM faculty in 2012. Through his leadership at BCM and major consortia like AMP- AD he continues to champion precision medicine strategies to resolve disease heterogeneity and develop personalized treatments for neurodegenerative disorders.